The pandemic undoubtedly has created a variety of. Barcelona clinic liver cancer-stage C (BCLC-C) encompasses a broad spectrum of tumor burdens, liver function statuses, patient prognoses, and treatment strategies. If you have enrolled in BCLC's Voluntary Self-Exclusion/Game Break program please refrain from taking this survey. For example, if the New England Patriots were favored to win against the New York Jets by 2. If you or someone you know has a problem with gambling, please call. Keno & Keno Bonus. It consists of three business units, Lottery, Casino and eGaming; and five support divisions, Human. 31. BCLC staging and treatment strategy in 2022. by BCLC. Portal vein invasion (PVI) and extrahepatic spread (ES) are two tumor-related factors that define advanced stage in the Barcelona Clinic Liver Cancer (BCLC) staging system (BCLC stage C), and the. Step 3:. residents can double their impact by shopping local. In point spread betting, a tie is called a “push. BCLC stage C comprises advanced HCC with vascular invasion, extrahepatic metastasis, and mild cancer-related symptoms or. Keno, Keno Bonus, Keno Pattern Play, Keno Doubler and Keno Value Bundles Game Conditions. Point spread: Raiders (-1. Approximately 80%. 0, AFP 90, and DCP 500 were defined as the value. The BCLC intermediate stage, or stage B (BCLC-B), includes Child-Pugh A and B patients with large, single-focus HCC (>5 cm) and patients with multifocal HCC, defined as >3 tumors of any size, or 2–3 tumors with a maximal diameter >3 cm. As well known, the intermediate stage is defined as multifocal HCC (beyond BCLC-A criteria; see Figure 1) with preserved liver function, no cancer-related symptoms, and no vascular invasion or extrahepatic spread. 3. This distinction allowed the development of the first Barcelona Clinic Liver Cancer (BCLC) staging system. Play the lottery in BC and check winning numbers | BCLCIn fact, from a prognostic point of view, BCLC-B patients are grouped together regardless of whether they are Child-Pugh A or B (thus, the flowchart is complete and correct). We performed a real-world, retrospective analysis of the surveillance strategy for BCLC stage B HCC patients after radical therapy with CR to. Oddset Before you can play the game, you need to learn the game. In BCLC stages 0-B, HCC-related and non-HCC-related deaths significantly differed between younger and older individuals (p = 0. 88: 2. com, login to your account and access “Game Break” from within the “My Account” section. Point spreads (also referred to as lines or handicaps) are also accompanied by odds. Moneylines; Totals. To voluntarily self-exclude from PlayNow. can now play Canucks 50/50 jackpots from the comfort of their living room thanks to a new online 50/50 raffle on. BCLC stage C HCC represents a large spectrum of disease with poor prognosis and constitutes the majority of HCC patients. Methods: A total of 323 consecutive patients in BCLC stage C with PS 1 but without vascular invasion or extrahepatic spread were enrolled in this retrospective study. Vascular invasion, extrahepatic spread: Terminal stage (D) 3-4: C: Any: Stage 0, A, and B, all criteria should be fulfilled. Survival analyses were performed using the Kaplan-Meier analysis, and statistical differences between the TACE and sorafenib groups. Same Day Cash Payout*. Point spread: Cowboys (-1. Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and is a leading cause of cancer-related death worldwide. T: 250-828-5500. No. College basketball spreads are a fantastic way to get even odds on a favorite you think will win the competition without a sweat – likewise, it lets you cheer for underdogs with a bit of a cushion. 5 total which has since fallen two points. Barcelona clinic liver cancer (BCLC) staging uses a set of criteria to guide the management of patients with hepatocellular carcinoma (HCC). In Ontario, the games are called Proline while they are. They won back-to-back Grey Cups in 2019 and 2021 (2020 was wiped out by the pandemic) and fell one point short of a three-peat last year when Toronto upset them 24-23. Learn about the odds of winning and the prizes you could win playing Daily Grand. Free NFL Point Spread Picks. - Hockey fans across B. Poor response rates further hamper outcomes for those that are. 1. Hepatocellular carcinoma (HCC) is one of the major complications of cirrhosis and chronic hepatitis B. For liver cancer in adults, stages are also grouped according to how the cancer may be treated: Localized liver cancer has not spread outside the liver and can be removed by surgery. Background and aims: The Barcelona Clinic Liver Cancer (BCLC) staging system is the algorithm most widely used to manage patients with hepatocellular carcinoma (HCC). The BCLC staging system is relatively unique given its incorporation of stage-based treatment recommendations . Claims. In 2021/22, thanks to our players, BCLC generated $1. There are. Decide how many consecutive plays (up to 99) Set your wager - $1, $2, $5 or $10 per draw. Gilgeous-Alexander leads Oklahoma City against Philadelphia after 40-point performance. 0/5. Sport Select is a group of betting games that the Western Canada Lottery Corporation offers to residents of Saskatchewan and Alberta as well as Manitoba, the Yukon, and the Northwest Territories. Overtime counts if played, and there are a selection of related betting markets to add extra value, choice and excitement, such as totals, moneyline, winning margin NFL betting, and the like. rookies. Scratch & Win. “ATS” implies the win based on bets against the spread. O. billion. ET FRIDAY: The Badgers hit BetMGM's college football Week 2 odds board as 4. NFL Week 12 over/unders (point totals): Green Bay Packers at Detroit Lions: 46. 68: 1. Point Spread: Pick the outcome of two to 12 games with a point spread factored in. To calculate “+” odds, divide the odds by 100 and multiply that product by the amount of the wager. Take the NFL for example. Jordi Bruix, MD: The TNM staging system has never been, really, a good predictive outcome in patients with liver cancer, because it just takes into account tumor burden and TNM. 5. 1 Management of intermediate-stage HCC (Barcelona Clinic Liver Cancer [BCLC] stage B) remains challenging because of the heterogeneity of tumor characteristics at this stage. Address: BCLC group, Liver Unit, ICMDM, CIBERehd, IDIBAPS, Hospital Clínic, c/ Villarroel, 170, Escala 11, 4a planta, 08036 Barcelona. Includes the odds, moneyline, and over/under on the current and opening line. Event where BCLC determines the outcome by any method other than completion of the Sports Action Event. A total of 605 patients with HCC were treated with the first TACE procedure during the abovementioned period. Pittsburgh Steelers at Cleveland Browns: 33. Of those, PVI and ES are. Point spread Most times, particularly at high levels of professional sport, the competitors have very close talent levels, and therefore the handicap winds up on the smaller side. 5, and juice usually is a plus number. Hepatocellular carcinoma (HCC) is a major health concern worldwide and the third cause of cancer-related death [ 1, 2 ]. Contests & Promotions. com. 5) Home (+0. If the spread is set at +7, the underdog must either win the game outright or lose by. A similar heterogeneity of tumour burden and liver function can be found among patients classified as BCLC stage C, which includes diverse clinical features (performance status [PS] 1–2), macrovascular invasion (MVI) including portal vein tumour (PVT) thrombosis, and/or extra-hepatic spread. Includes the odds, moneyline, and over/under on the current and opening line. “Total O/U” represents the amount. 14 to 0. You feel well and are active (PS 0), and your liver is working well (Child. The betting line will almost always be different than -110, as 1. Cirrhosis, probable or definite. We’re very happy about that. Final results are at the end of the fight. BCLC New Owner Guide APPENDIX: SAMPLE COURIER MATERIALS 1. BC/49 & Extra. To slow the spread of COVID-19, all casinos, community gaming centres and bingo halls across B. Using an online sportsbook simplifies the betting process. Pacific Hold'Em Poker. It divides liver cancer into 4 main stages, from 1 to 4. Scratch & Win. 2 The BCLC algorithm is endorsed by the European and American clinical practice guidelines, 3, 4 whereas in Japan, for example, other guidelines are followed. As a rule, the lower the number, the less the cancer has spread. The -ALBI score had an optimal cut-off value of 2. In 2014, BCLC officially expanded to all states in the Southeast region. To cover a spread, the selected team must beat the point spread that was assigned. GameSense is here to help keep gambling a safe, fun source of entertainment. A sharp increase in the number of visitors to Macau has led to an upgrade in analysts’ earnings outlook for casinos,bclc bingo even as the prospect for the broader Chinese market remains tepid. , if patients in BCLC stage C with PS 1 do not have vascular invasion or extrahepatic spread, more aggressive locoregional therapy could be attempted before choosing a systemic chemotherapy such as sorafenib . We aimed to investigate the prognostic value of BDI and the stage of BDI in different staging systems. 99 may be claimed by mailing your ticket to the Kamloops Player Services office at: As reported by Zhao et al. 09 – your original $10 comes back along with your $9. 75. 5-point favorites for MNF. Moneyline: Giants win as +135 underdogs (bet $10 to win $23. The tumor is smaller than 2 centimeters (cm). See what's new. As well known, the intermediate stage is defined as multifocal HCC (beyond BCLC-A criteria; see Figure 1) with preserved liver function, no cancer-related symptoms, and no vascular invasion or extrahepatic spread. Jackpots of $10-$70 million. The expected outcome is expressed as median survival of each tumour stage according to the available scientific evidence. Since 1985, BCLC has been a proud sponsor of events in local communities throughout the province. Build your perfect parlay. “To Win” represents the win based on outright or moneyline bets. That’s a difference of $135 on a $10 bet. You can also visit the BCLC offices in Kamloops or Vancouver, call BCLC's Consumer Services at 1-866-815-0222, or visit. As an agent of government, the BC Lottery Corporation (BCLC) conducts, manages, and operates most. For a football game to have action, the game must be played for at least 55 minutes actual play. Let's take the 2022 Super Bowl example: Rams -4. According to the BCLC staging system, resection is the first line of11-01-2023 • 11 min read. Point Spreads. A spread is a range of outcomes and the bet is whether the outcome will be above or below the spread. $ 113. C. All tickets that win over $2000 and are claimed via mail, requires a mail declaration form to be printed, completed and signed. Manage Your Play Encore Rewards Promotions Winners . (See "Epidemiology and risk factors for hepatocellular carcinoma" . The underdog will have odds with a positive number next to it, and the favored team will have a negative number next to it. 50 total); Commanders were -160 favorites (bet $10 to win. Also known as the "juice" or "vig," if you see NFL Vegas odds of -11. The over/under is. 4% in BCLCC. While most gamblers will focus on the spread and total, there are countless games within the big game that even novice gambling fans. FanDuel Sportsbook offers college basketball odds, including spreads, moneylines, over/under point totals, and prop bets for every college basketball game from the regular season games through the NCAA Tournament in March. tumor size. 5 means the team must win by more than. It’s also often labelled as 1×2 or 3-way betting. ET Sunday (FOX) UPDATE 1 P. Fig. We have the best cappers and NFL picks on the market and you can get all of our NFL picks for free! every week. radiologic tumor extent. gov means it's official. 5 years. NCAA basketball odds will be released daily, and these betting odds will be refreshed up to the minute on our. 133. It’s played using a selection slip similar to lottery games with betting options such as Oddset, Point Spread, Over/Under, Props and Toto. For BCLC B stage HCC (BBHCC) cases with large multifocal tumors and without vascular invasion or spread outside of the liver, transarterial chemoembolization (TACE) is recommended if liver function is maintained. PRO•LINE, POINT SPREAD and OVER/UNDER final results do not include OT or shootouts. BCLC staging and treatment strategy in 2022. Sports Action Toto Game Conditions and Prize Structure Sports Action Over Under Game Conditions and Prize Structure Sports Action Point Spread Game Conditions and Prize. 6% (n = 52) in BCLC-C (Figure 1). The BC/49 $2 million top prize will be shared if there is more than one winning selection. 2 More than 80% of HCC. Prizes and odds of winning: main prize Overall odds of winning any prize per $1. When betting on the underdog at +160, you'd bet $100 to win $160 if the underdog wins. We are dedicated to bringing you the best betting picks, odds, and overall sports analysis that you will find anywhere. 8%: Proline Odds: 1. Campbell vs. and supporting local businesses in 11 communities. First off, any spread that’s a – is a favorite. Whilst there have been advances in all areas, we will focus on those that have led to a change in strategy and we will discuss why, despite. Keno & Keno Bonus. If you have enrolled in BCLC's Voluntary Self-Exclusion program please refrain from taking this survey. British Columbia Lottery Corporation is upping its efforts against problem gambling, as the Crown agency makes updates to its Game Break self-exclusion program. Background Although the Barcelona Clinic Liver Cancer (BCLC) staging system has been largely adopted in clinical practice, recent studies have questioned the prognostic stratification of this classification schema, as well as the proposed treatment allocation of patients with a single large tumor. If you bet on an underdog, they can lose by fewer than the assigned spread or win outright for you to win. 28 per 100,000 in men under 30 years of age and has risen from 0. Thirty-seven patients without vascular invasion or extrahepatic spread who were classified as BCLC C because of compromised performance status (ECOG 1–2) received HCC therapy according to the number and size of tumors as follows: liver transplant (n=2), resection for a single nodule without portal hypertension (n=5), RFA or PEI (n=9), or TACE. Includes the odds, moneyline, and over/under on the current and opening line. , Point Spread, Money Line, Over/Under, etc. A flowchart of the BCLC guidelines is shown in Figure 8 [19]. You've got two options for how you'll get there. In case of positive SLNB, regional lymph node. In Western Europe, the incidence of liver cancer has doubled from 0. NFL Week 11 over/under. Picks are Settled on the official result published by the governing body or as otherwise verified by BCLC. 5, dipping a point to -22. The team you bet on has to ‘cover’ or beat that margin for you to win your bet. How to Play Over / Under Think the game is going to be an offensive. Thus, in our study, we defined the BCLC-B stage as patients with Child scores of A or B with large, single-focus HCC (>5 cm) and those with multifocal HCC, which is defined as >3 tumors of any size or 2 to 3 tumors with a maximal diameter of >3 cm in the absence of vascular invasion or extrahepatic spread. The BCLC system establishes a prognosis in accordance with the 5 stages that are linked to first-line treatment. Lotto 6/49. San Francisco 49ers at Seattle Seahawks: 42. Find out all of the great Lotto 6/49 and Extra prizes available to be won and the odds of winning them. This shows that even with far better online betting options available to residents of WCLC provinces the betting lottery is still bringing in significant revenue at profit margins that are expected to be 30-40% if. Median OS was not reached for BCLC stage 0, and was 80, 27, 15 and 4 months for BCLC stages A, B, C and D respectively (P < 0. 1 Liver transplantation and hepatectomy are both viable treatment strategies for treating HCC. Management of HCCMoney Line: Green Bay Packers (+150) ; Pittsburgh Steelers (-175) Total: 38. Pull Tabs. M. Houston Texans quarterback Davis Mills (10) looks to pass during an NFL preseason game against the San Francisco 49ers on Thursday, August 25, 2022, in Houston. However, if there has been a conclusive result in a Market at the time of abandonment, all bets on that Market. sports bettors a. In order for a comparable potential winning payout to a player, more money must be risked to bet the favoured team; less money on the weaker team. 2 months) or. 05). Select your games and see your potential winnings. We would like to show you a description here but the site won’t allow us. 5 points, while a +5. This information must be displayed at point of sale, including all lottery retail outlets; and. Get free college football picks for every game of the 2023-24 including college football picks against the spread, straight-up, money line picks, and totals picks (over/under). CA register The inverse probability weighting (IPW) method was adopted to balance the confounders between. New to Sports betting?The advanced stage, BCLC stage C, is defined for the group of patients with adverse predictors, which includes patients with cancer-related symptoms, portal vein invasion (PVI), extrahepatic spread (ES), or a combination of these factors, in patients with preserved liver function, defined by Child-Pugh Class A or B . A ½ point is added to BCLC’s Point Spread to eliminate tie results. Among the 125 HCC patients, 40 patients had history of HCC without viable tumor. When the jackpot reaches $50 million, additional $1 million MAXMILLIONS prizes are added. Bet Cooper Kupp to go over 7. ET. m. The Barcelona Clinic Liver Cancer (BCLC) system is the most commonly used staging system for hepatocellular carcinoma (HCC) in Western countries. Online. 5 points scored Time: 10 p. Hepatocellular carcinoma (HCC) is the most common primary cancer of the liver. Step Six Use the Purolator PIN number to track your shipment at If you require additional information regarding Buybacks, contact the BCLC Lottery Support Hotline at: 1-800-667-1649. Hepatocellular carcinoma is a primary liver cancer that occurs most commonly in patients with cirrhosis. It stratifies prognosis by integrating albumin-bilirubin score and alpha fetoprotein for additional granularity, particularly for BCLC stage B. Turn up the fun and the excitement and get up to a $150 match deposit when you bet with PlayNow Sports. com, login to your account and access “Game Break” from within the “My Account” section. However, the extent of PVI and the type of ES. The second novelty in this update is the recognition of liver transplantation (LT) as one of the main objectives. To help, BCLC is launching Spread the Local Love, an online fundraising campaign, running from February 1 to 15. Draws every Wednesday and Saturday!Pick up a current Sports Action Point Spread Menu here or at your local Lottery Retailer. 5. To this point, the original BCLC system was updated in 2011 to designate solitary large HCC (≥ 5 cm) as BCLC-A rather than BCLC-B,27 acknowledging that resection, rather than other locoregional therapies,. A PRO•LINE TIE occurs when the fight ends in a draw. BC/49 Game Conditions and Prize Structure. The BCLC system establishes a prognosis in accordance with the 5 stages that are linked to first-line treatment recommendation. g. 5-point underdog in the latest Week 1 NFL odds at Caesars Sportsbook, one of the larger NFL spreads this week. 95 including the original $100 risked across the two separate bets. In BCLC stage 0-B, all-cause mortality increased with age and increased rapidly around the age of 40 years (non-linear, p < 0. OS from first HCC treatment by BCLC stage is shown in Fig. To voluntarily self-exclude from PlayNow. 3. The BCLC system identifies. Indianapolis Colts South Point and Wynn are two of the last sports books on Earth with the half-point hook still attached on the Texans to make this a must-play. Abstract. Title: Host Local Government Payments for Fiscal Year. Celtics odds. ” In the case of a push, all bets are returned to the bettor. BCLC stage C comprises advanced HCC with vascular invasion, extrahepatic metastasis, and mild cancer-related symptoms or both (ECOG PS 1–2). Sorafenib treatment is the only available option for well-moderate compensated cirrhotic patients with Barcelona Clinic Liver Cancer stage B (BCLC-C) advanced hepatocellular carcinoma (HCC) stage or with BCLC-B intermediate HCC with tumour progressing after ineffective loco-regional therapies [1,2,3,4,5,6,7,8,9]. It is based in Kamloops, with a secondary office in Vancouver. Hepatic resection has the highest local controllability that results in long-term survival for hepatocellular carcinoma (HCC). As reported by Zhao et al. Used to calculate. If you have any questions, please contact BCLC Customer Support at 74 West Seymour Street Kamloops, BC V2C 1E2 or telephone 1-877-706-6789. Pacific Hold'Em Poker. Because it can take years for cancer cells to travel from the capsule to other areas of the body, the amount of time it takes Bia-ALCL to spread is unpredictable. Page 9 - Come discuss Sports Lottery before you place your bets. The Barcelona Clinic Liver Cancer (BCLC) staging system was. The Barcelona Clinic Liver Cancer (BCLC) staging. We aimed to investigate the extent to which the BCLC recommendations effectively guide clinical practice and assess the reasons for any deviation from the. However, the tumour burden may be quite heterogeneous in this stage, and prognosis is also influenced by the degree of liver. The Barcelona Clinic Liver Cancer (BCLC) staging system has been recommended to be the prognostic model and also the allocating tool of primary anti-cancer treatment by major academic societies for liver diseases [1, 2]. PROPS final results include OT but not shootouts. 5 points on the spread, but in baseball it’s. 5. This system accounts for functional status of the liver and tumor characteristics [24, 25]. Miami Dolphins at New. 1. If there are 3 outcomes with one being a draw then it is a typical 3-way bet. Stage A – There is one tumour in the liver that is smaller than 5cm across. You've got two options for how you'll get there. BCLC. College Football Picks. Action Event where BCLC determines the outcome by any method other than completion of the Sports Action Event. Parlay Calculator. Without a point spread, bettors have to risk a bit more to bet the favorite, but you earn a. Totals; Player Props. If there are more than six 5/6+ Bonus winners ($75,000 prize), each winner will share in. When Encore Rewards Accounts are merged, BCLC will advise the member that the Encore Rewards Accounts have been merged and that the Point(s) have been consolidated, except that a VSE or barred Program Member will be advised accordingly upon the expiry of their VSE or barring period. Hepatocellular carcinoma (HCC) is the most common form of liver cancer and accounts for ~90% of. ET FRIDAY: The Sooners are pinned to -20 at BetMGM, with the only adjustment coming this morning to -20 (-105). Action Event where BCLC determines the outcome by any method other than completion of the Sports Action Event. BC 50/50. You can control point spread by observing the line movement pre-game. Conversely, if the game ended 110-105, that would be a pooled score of 215 points, meaning the game went UNDER. 1 This update of the 2018 guidelines incorporates recent, practice changing trials of systemic therapies in patients with advanced HCC (BCLC C). Point spread betting in hockey. (f) “Odds” means the odds for a Sports Action Event as determined by BCLC (g) “Result” means: I. BCLC FAQs. Results. BCLC aims to categorize patients into five stages with different prognoses and to allocate treatment according to these stages based on the best possible contemporary evidence. This amount is the total profit (or loss) based on a bettor placing $100 on each of the last 100 college football picks made by the computer, on the opening and closing lines. Other factors, such as the BCLC stage, extrahepatic spread, baseline tumor marker (AFP/DCP) levels, ALBI grade, and FIB-4 index need to be considered in the management of patients with HCV-related HCC. The Sports Action betting options include Oddset 3-outcome, Oddset 2-outcome, point spread, over/under and props. A total, also known as an over/under, is a bet on the number of points both teams will combine to score in a game. 2∼33. March 3, 2021. Moneyline betting is when you pick the winner of the game or event. 44, the same below), presenting a specificity and a sensitivity of 56. BC/49 & Extra. (g) “OVER/UNDER” means, where applicable, whether the Result of the Sports Action Prop will be greater than (Over) or less than (Under) BCLC’s Pre-set Line for that Sports Action Prop. Pacific Hold'Em Poker. stage A: early. 3 percent. It is a primary liver malignancy that is. BC/49 & Extra. We believe the Bible to be the inspired, infallible and authoritative word of God. The TNM classification for staging of hepatocellular carcinoma is provided below. 888 Sport Bonuses; Top Free Bets and Sign Up Offers. More than 70% of patients with HCC are diagnosed at intermediate- or advanced-stage disease and are ineligible for curative treatment (1,2). (BCLC). Building on the success of the award winning campaign, Spread the Local Love, BCLC is launching Love Local BC . 45. According to the BCLC, gambling and sports betting are legal only for those that are 19 or older. Keno. Rather than a point spread, bookmakers offer run line odds on baseball action. Here are all of the updated point spreads for the Week 11 games in the Big Ten: Rutgers at Indiana. 8%: Proline Odds: 1. However, some people with Bia-ALCL have. BCLC stage B group patients were distributed from HKLC stage I to III, and BCLC stage C group patients were distributed from HKLC stage II to V. 5 points, if you bet on Kansas City, it would only require the gambler to bet $110 to win $100. The treatment algorithm suggested by the BCLC classification homogenized the surgery group and in turn increased performance of outcome predictability of the BCLC classification. Surveillance. BET $100 TO WIN $91. But the spread may also give an underdog a chance to cover. 2018 Nov;37 (6):481-491. We compared it to other systems different from Wang et al’s study (Barcelona Clinic Liver cancer (BCLC) staging, Child-Pugh (CP. A lobectomy is a type of lung cancer surgery in which one lobe of a lung is removed because it contains malignant tumors. Example: If you want to bet a -180 favorite, you need to risk $180 to win $100 (or for smaller-stakes players, $18 to win $10). Learn more ». This includes regulatory oversight of the British Columbia Lottery Corporation (BCLC) (which conducts and manages lotteries, casinos. Interprovincial Lottery Corporation Rules and Regulations. The second novelty in this update is the recognition of liver transplantation (LT) as one of the main objectives. Liver cancer stages range from stage I (1) through IV (4). 5 (-110) Baylor covers by winning the game or by keeping the margin to two points or fewer, such as 69-68. ASO PERSPECTIVES Critical Analysis of the Updated Barcelona Clinic Liver Cancer (BCLC) Group Guidelines Diamantis I. Toto (Pools): Pick the outcome of all games in any Sports Action Toto Menu (13 games): Visitor Win, Home Win, or Tie. A -5. C. Keno & Keno Bonus. Based on these considerations and results of the current study, the 8th TNM staging system for HCC has better performance on prediction of long‐term outcomes in. [url=promote responsible gambling through public awareness and education, treatment and prevention, research, training, evaluation and policy development. The classification takes the following variables into account 1,2: performance status (PS) Child-Pugh score.